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- dysfunction of the lacrimal glands
- changes in the tear composition
- abnormalities in chemicals secreted by nerve cells
CONCLUSIONS OF THE RESEARCH: Conventional DMARDs are not particularly effective in treating the symptoms of dryness in the eyes in Sjogren's Syndrome (SS). These drugs are commonly prescribed for SS. Emerging evidence suggests that B cell and co-stimulatory targeted therapy may play a role in the future.
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| B cell activation |
B cell depletion has been associated with improvement in many (but not all) conditions associated with autoantibody production.
B cell targeted therapy for rheumatoid arthritis (RA) was developed with the objective of removing B cell clones responsible for the production of pathogenic autoantibodies. [1]. This has not been achieved yet but B cell depletion therapy has been found to have a major impact on RA in the short term.This post is my attempts to simplify medical research into Sjogren's Syndrome so that people with SS can understand: Here is the REFERENCE: Advances in the treatment of ocular dryness associated with Sjögren׳s syndrome. PubMed June 2015 Ciurtin C, Ostas A, Cojocaru VM, Walsh SB, Isenberg DA.
Find out more about DMARD's: what they are and specific ones.
Amazing post.
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