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EULAR Sjögren's syndrome disease activity index (ESSDAI)


what is EULAR Sjögren's syndrome disease activity index
The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS.

It is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure in current randomised clinical trials.

The ESSDAI is a systemic disease activity index that was created in 2009. It was developed by consensus of a large group of worldwide experts from European and North American countries, supported by the EULAR. The European League Against Rheumatism (EULAR) is the organisation which represents the people with arthritis/rheumatism, health professionals and scientific societies of rheumatology of all the European nations.

The ESSDAI includes 12 domains (ie, organ systems: cutaneous, respiratory, renal, articular, muscular, peripheral nervous system (PNS), central nervous system (CNS), haematological, glandular, constitutional, lymphadenopathic, biological).

The ESSDAI includes organ-by organ definitions that were agreed on by a large number of experts.

Each domain is divided into 3–4 levels of activity. Definition of each activity level is provided by a detailed description of what should be considered in that item.

The aim was to obtain a standardised instrument for the evaluation of systemic activity in order for the ESSDAI to be used as outcome criteria to evaluate primary SS in clinical trials as well as daily practice.

This tool has been validated in a large independent cohort and has been shown to have a high contentvalidity, to be highly reproducible and to be able to detect change.


This information is OPEN ACCESS from Seror R, Bowman SJ, Brito-Zeron P, et al. EULAR Sjögren’s syndrome disease activity index (ESSDAI): a user guide. RMD Open 2015;1:e000022. doi:10.1136/rmdopen-2014000022

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