tag:blogger.com,1999:blog-4801409725390706762024-03-13T16:53:49.290-07:00sjogrens blogpronounced show grins (but i'm not grinning)Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.comBlogger64125tag:blogger.com,1999:blog-480140972539070676.post-24849354608988761272019-10-01T23:41:00.000-07:002019-11-04T18:48:20.021-08:00Supervised walking program for Sjogren's syndrome<div class="AbstractSection" id="ASec1" style="background-color: #fcfcfc; box-sizing: border-box; color: #333333; font-size: 17px; font-style: normal; font-weight: 400; letter-spacing: 0.1px; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
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<span style="font-size: small;"></span><a href="https://1.bp.blogspot.com/-btfC5Xc3VYg/XZRH9fTZ_TI/AAAAAAAAAn4/rpqdlDpjpNsBgsrtKM8KZG6HGdKtPvlwACLcBGAsYHQ/s1600/Sjogren%2527s%2BBlog%2B%25282%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="walking program for Sjogren's syndrome" border="0" data-original-height="810" data-original-width="540" height="640" src="https://1.bp.blogspot.com/-btfC5Xc3VYg/XZRH9fTZ_TI/AAAAAAAAAn4/rpqdlDpjpNsBgsrtKM8KZG6HGdKtPvlwACLcBGAsYHQ/s640/Sjogren%2527s%2BBlog%2B%25282%2529.jpg" title="Supervised walking program for Sjogren's syndrome" width="426" /></a></div>
Objective</span></h3>
<div class="Para" id="Par1" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="font-family: inherit;">The aim of this study was to evaluate the safety and effectiveness of a supervised walking program in women with primary Sjögren’s syndrome (pSS).</span></div>
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Methods</span></h3>
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<span style="font-family: inherit;">Forty-five sedentary women fulfilling the American European Consensus Criteria for pSS were randomly placed into one of two training groups: 23 were placed in TG (Target Group)and 22 in CG (Control Group) </span></div>
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<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">The following were assessed:</span></div>
<ul>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="font-family: inherit;"><span style="background-color: transparent; color: #333333; display: inline; float: none; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Physical fitness [maximum oxygen uptake </span><span style="background-color: transparent; color: #333333; display: inline; float: none; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">and distance] </span></span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><a href="https://sjogrenssyndrome.blogspot.com/2019/10/eular-sjogrens-syndrome-disease.html" target="_blank">EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) </a></span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="font-family: inherit;">H<span style="background-color: transparent; color: #333333; display: inline; float: none; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">ematological tests</span></span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Medical Outcomes Study 36 (SF-36) </span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) </span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><a href="https://consultgeri.org/try-this/general-assessment/issue-30.pdf" target="_blank">Functional Assessment of Chronic Illness Therapy Fatigue Subscale </a>(FACIT-fatigue)</span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Beck Depression Inventory (BDI) </span></div>
</li>
<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Patient global assessment of response to therapy was completed at the final assessment. </span></div>
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<li><div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-family: inherit; font-size: 17px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: 0.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">An intent-to-treat analysis was performed.</span></div>
</li>
</ul>
<div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="font-family: inherit;">Patients in the TG joined in supervised walking three times a week for 16 weeks. </span></div>
<div class="Para" style="box-sizing: border-box; margin-bottom: 1.2em; margin-top: 1em; overflow-wrap: break-word; word-break: break-word;">
<span style="font-family: inherit;">The patients of the CG were instructed not to do any kind of regular physical exercise for the 16 weeks. </span></div>
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Results</span></h3>
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After 16 weeks, the average changes were higher in the TG than in the CG. </div>
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Improved cardiorespiratory fitness was associated with improvements in fatigue scores and physical components of quality of life. Cardiorespiratory fitness refers to the ability of the circulatory and respiratory systems to supply oxygen to skeletal muscles during sustained physical activity. Improved fatigue scores were associated with reduced depression and improvements in the physical and mental components of SF-36.<br />
<br />
Overall, 95.4% of patients in the TG rated themselves as clinically improved versus 62% of the patients in the CG. There was no flare in disease activity and no serious adverse events with exercise.</div>
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<span style="font-family: inherit;"><span style="font-size: small;"></span></span></div>
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Conclusions</span></h3>
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<blockquote class="tr_bq">
<i><span style="font-family: inherit;">This supervised walking program was demonstrated to be feasible and safe with improvements in cardiorespiratory fitness, exercise tolerance, fatigue, and patient perception of improvement in pSS patients.</span></i></blockquote>
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<a href="https://1.bp.blogspot.com/-T-MWtUB4LN8/XZRJrBUwShI/AAAAAAAAAoE/ORzdQ76hmycnkD9Q8h1txP3qbUEgoVizwCLcBGAsYHQ/s1600/benefits-of-walking-lose-fat.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><span style="font-family: inherit; font-size: small;"><img alt="" border="0" data-original-height="736" data-original-width="736" height="400" src="https://1.bp.blogspot.com/-T-MWtUB4LN8/XZRJrBUwShI/AAAAAAAAAoE/ORzdQ76hmycnkD9Q8h1txP3qbUEgoVizwCLcBGAsYHQ/s400/benefits-of-walking-lose-fat.jpg" title="Benefits of walking" width="400" /></span></a></div>
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<span style="font-family: inherit; font-size: x-large;"><b>If you want to do this walking program yourself this is how it was done: </b></span><br />
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E<span style="font-family: inherit;">ach training session was preceded by a warm-up period, where patients were instructed to walk freely and slowly for 5 minutes, followed by 20 to 50 minutes of effective walking when they were instructed to maintain their paces to achieve the target heart rate and ending by a cold-up period for 5 minutes (similar to warm-up period).</span><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 24px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><br /></span></span></div>
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<span style="font-family: inherit;">The exercise prescription was based on the heart rate at the anaerobic threshold determined at the initial assessment. The increment of intensity exercise was based on time: 30 in the first 2 weeks, adding 5 minutes per week until eighth week, completing 60 minutes, which remains until the end.</span><span style="font-family: inherit; font-size: x-large;"><br /></span></div>
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<span style="font-family: inherit; font-size: x-large;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30604204" target="_blank">Source</a>:</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: transparent; box-sizing: border-box; color: black; font-variant: normal; letter-spacing: normal; line-height: 24px; margin: 0px 0px 7.8px; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
<span style="background-color: transparent; color: black; display: inline; float: none; font-family: "arial" , "helvetica" , "clean" , sans-serif; font-size: 18.2px; font-style: normal; font-variant: normal; font-weight: 700; letter-spacing: normal; line-height: 22.75px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30604204" target="_blank">Supervised walking improves cardiorespiratory fitness</a>, exercise tolerance, and fatigue in women with primary Sjögren's syndrome: a randomized-controlled trial.</span></div>
<span style="font-family: inherit;"><b><i><br /></i></b></span>
Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-52248811384826863382019-09-29T22:59:00.003-07:002019-09-29T23:02:16.249-07:00Cold weather tips from people with Sjogren's syndrome<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-n8cp9_MpjZ4/XZGYe87pcDI/AAAAAAAAAnQ/fDjYJW74J3YPAHHZh31a3axSMhmo43WSgCLcBGAsYHQ/s1600/OneCOLD%2BWEATHER%2BTIPS%2BFROM%2Bby%2Bpeople%2Bwith%2BSS_%2Bwear%2Bgloveswear%2Blots%2Bof%2Blayers%2Bof%2Bclothingsome%2Bsay%2Bwear%2Bcotton%2Blayer%2Bnext%2Bto%2Bskin%252C%2Bsome%2Bsay%2Bsynthetic%2Bnext%2Blayer%2Bcould%2Bbe%2Bwool%2Bor%2Bpolar%2Bfleece.%2BOuter%2Blayers%2Bwill%2Bideall.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Cold weather tips for Sjogren's syndrome" border="0" data-original-height="1600" data-original-width="640" height="640" src="https://1.bp.blogspot.com/-n8cp9_MpjZ4/XZGYe87pcDI/AAAAAAAAAnQ/fDjYJW74J3YPAHHZh31a3axSMhmo43WSgCLcBGAsYHQ/s640/OneCOLD%2BWEATHER%2BTIPS%2BFROM%2Bby%2Bpeople%2Bwith%2BSS_%2Bwear%2Bgloveswear%2Blots%2Bof%2Blayers%2Bof%2Bclothingsome%2Bsay%2Bwear%2Bcotton%2Blayer%2Bnext%2Bto%2Bskin%252C%2Bsome%2Bsay%2Bsynthetic%2Bnext%2Blayer%2Bcould%2Bbe%2Bwool%2Bor%2Bpolar%2Bfleece.%2BOuter%2Blayers%2Bwill%2Bideall.jpg" title="Cold weather tips from people with Sjogren's syndrome" width="256" /></a></div>
These tips for coping with Sjogren's syndrome in cold weather come from members of the Sjogren's blog facebook page. You can join this page by following it<a href="https://www.facebook.com/Sjogrens-blog-233053606739810/" target="_blank"> here on facebook</a>.Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-44631885592505219152019-09-15T19:44:00.000-07:002019-09-15T20:17:31.423-07:00Ten natural cough remedies<div class="separator" style="clear: both; text-align: center;">
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<a href="https://1.bp.blogspot.com/-HkAFyfkN_5E/XX7-gnz-FJI/AAAAAAAAAmQ/aeVMVPxgOIMGjNo_31N8K9BDWTc2eaFRgCLcBGAsYHQ/s1600/Natural%2Btreatments%2Bfor%2Ba%2Bcough%2B%25281%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="10 natural treatments for a cough" border="0" data-original-height="1102" data-original-width="735" height="640" src="https://1.bp.blogspot.com/-HkAFyfkN_5E/XX7-gnz-FJI/AAAAAAAAAmQ/aeVMVPxgOIMGjNo_31N8K9BDWTc2eaFRgCLcBGAsYHQ/s640/Natural%2Btreatments%2Bfor%2Ba%2Bcough%2B%25281%2529.jpg" title="Ten natural cough remedies" width="425" /></a></div>
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;">Many people with Sjogren's develop a cough <span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">because of dryness in the air passages. </span></span></span></span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"></span></span></span><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;"><br />Sjogren's is a systemic disease and treatment for a dry cough caused by SS should be treated by a medication/treatment that treats the whole body. </span></span><br />
<span style="color: black;"><br /></span>
<span style="color: black;">M<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;">any people, for a variety of reasons, do not fare well on these medications and choose to try complementary treatments. Here are 10 natural cough remedies (which were reviewed by a doctor): </span></span></span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;"></span><br /></span></span>
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;"><b>1. Honey tea</b>: mix 2 teaspoons (tsp) with warm water or an herbal tea. Drink this mixture once or twice a day.</span></span></span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;"></span><br /></span></span>
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;"><b>2. Ginger</b>: Brew up a soothing ginger tea by adding 20–40 grams (g) of fresh ginger slices to a cup of hot water. Allow to steep for a few minutes before drinking. Add honey or lemon juice to improve the taste and further soothe a cough.</span></span></span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><span style="color: black;"></span><br /></span></span>
<span style="color: black;"><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><b>3</b></span></span><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="font-family: inherit;"><b>. Warm Fluids</b>: beverages that may be comforting include:</span></span></span><br />
<ul>
<li><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;">clear broths</span></span></li>
<li><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;">herbal teas</span></span></li>
<li><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;">decaffeinated black tea</span></span></li>
<li><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;">warm water</span></span></li>
<li><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><span style="color: black; font-family: inherit;">warm fruit juices</span></span></li>
</ul>
<div>
<span style="background-color: white; color: #59626a; display: inline; float: none; font-style: normal; letter-spacing: normal; text-indent: 0px; text-transform: none; white-space: pre-wrap; word-spacing: 0px;"></span><b>4. Steam</b>: Take a hot shower or bath and allow the bathroom to fill with steam. Stay in this steam for a few minutes until symptoms subside. Drink a glass of water afterward to cool down and prevent dehydration.</div>
<div>
<br /></div>
<div>
<b>5. Marshmallow root</b><span style="background-color: white; color: #005000; font-family: "arial";">:</span> Add hot water to <span style="font-family: inherit;">either <span style="background-color: transparent; color: black; display: inline; float: none; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">dried herb or a bagged marshmallow root tea</span> </span>and then drink it immediately or allow it to cool first.</div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Marshmallow root is available to purchase in health stores or <a href="https://www.amazon.com/gp/search/ref=as_li_qf_sp_sr_tl?ie=UTF8&tag=cowbochron-20&keywords=marshmallow Root&index=aps&camp=1789&creative=9325&linkCode=ur2&linkId=ab7bdb0cd706f90c5a4ee3ab89e6e20d" target="_blank">online</a><img alt="" border="0" height="1" src="//ir-na.amazon-adsystem.com/e/ir?t=cowbochron-20&l=ur2&o=1&camp=1789" style="border: none !important; margin: 0px !important;" width="1" />.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;"><b>6. Bromelain</b> has anti-inflammatory properties. </span><span style="font-family: inherit;">Some people drink pineapple juice daily to reduce mucus in the throat and suppress coughing. However, there may not be enough bromelain in the juice to relieve symptoms.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;"><a href="https://www.amazon.com/gp/search/ref=as_li_qf_sp_sr_tl?ie=UTF8&tag=cowbochron-20&keywords=Bromelain supplements&index=aps&camp=1789&creative=9325&linkCode=ur2&linkId=73261ef9c7b13e1b6414f5ec06057b9b" target="_blank">Bromelain supplements</a><img alt="" border="0" height="1" src="//ir-na.amazon-adsystem.com/e/ir?t=cowbochron-20&l=ur2&o=1&camp=1789" style="border: none !important; margin: 0px !important;" width="1" /> are available and may be more effective at relieving a cough. However, it is best to speak with a doctor before trying any new supplements. People who take blood thinners or specific antibiotics should not take bromelain.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;"><b>7. Thyme </b>is a common remedy for a cough, a sore throat, and digestive issues. To treat coughs using thyme, look for a cough syrup that contains this herb. Alternatively, make thyme tea by adding 2 tsp of dried thyme to a cup of hot water. Steep for 10 minutes before straining and drinking.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">8. <b>Dietary changes</b> for acid reflux which is a common cause of a cough. Avoiding foods that can trigger acid reflux is one of the best ways to manage this condition and reduce the cough that accompanies it.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">The foods and beverages that most commonly trigger acid reflux include:</span></div>
<ul style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; display: block; font-style: normal; font-weight: 400; letter-spacing: normal; list-style: none; margin: -10px 0px 25px 12px; orphans: 2; overflow: hidden; padding-left: 20px; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">alcohol</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">caffeine</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">chocolate</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">citrus foods</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">fried and fatty foods</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">garlic and onions</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">mint</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">spices and spicy foods</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">tomatoes and tomato-based products</span></li>
</ul>
<h3 style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; clear: both; color: #231f20; display: block; font-style: normal; letter-spacing: normal; line-height: 26px; margin: 10px 0px 20px; orphans: 2; padding: 20px 0px 5px; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit; font-size: small;">9. Slippery elm</span></h3>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Make slippery elm tea by adding 1 tsp of the dried herb to a cup of hot water. Steep for at least 10 minutes before drinking. It is important to note that slippery elm can interfere with the absorption of medications.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Slippery elm is available in powder and capsule form in health stores and <a href="https://amzn.to/2IElej1" rel="noopener" style="background-color: transparent; border-bottom: none; box-sizing: border-box; color: #05a2d3; outline: 0px; text-decoration: none;" target="_blank"></a><a href="https://www.amazon.com/gp/search/ref=as_li_qf_sp_sr_tl?ie=UTF8&tag=cowbochron-20&keywords=Slippery elm&index=aps&camp=1789&creative=9325&linkCode=ur2&linkId=e908cdb5386e29ff052a708fb5d0cf47" target="_blank">online</a><img alt="" border="0" height="1" src="//ir-na.amazon-adsystem.com/e/ir?t=cowbochron-20&l=ur2&o=1&camp=1789" style="border: none !important; margin: 0px !important;" width="1" />.</span></div>
<h3 style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; clear: both; color: #231f20; display: block; font-style: normal; letter-spacing: normal; line-height: 26px; margin: 10px 0px 20px; orphans: 2; padding: 20px 0px 5px; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit; font-size: small;">10. Probiotics</span></h3>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; clear: both; color: #231f20; display: block; letter-spacing: normal; line-height: 26px; margin: 10px 0px 20px; orphans: 2; padding: 20px 0px 5px; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Probiotics do not directly relieve a cough, but they may boost the immune system by balancing the bacteria in the gut.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">A superior immune system can help to fight off infections or allergens that may be causing the cough.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Supplements containing <em style="box-sizing: border-box;">Lactobacillus</em> and other probiotics are available at health stores and drug stores.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">Some foods are also naturally rich in probiotics, including:</span></div>
<ul style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; display: block; font-style: normal; font-weight: 400; letter-spacing: normal; list-style: none; margin: -10px 0px 25px 12px; orphans: 2; overflow: hidden; padding-left: 20px; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">miso soup</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">natural yogurt</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">kimchi</span></li>
<li style="box-sizing: border-box; line-height: 26px; margin: 15px 0px 0px; position: relative;"><span style="font-family: inherit;">sauerkraut</span></li>
</ul>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">However, the number and diversity of probiotic units in foods can vary greatly. It may be best to take <a href="https://www.amazon.com/gp/search/ref=as_li_qf_sp_sr_tl?ie=UTF8&tag=cowbochron-20&keywords=probiotic supplements&index=aps&camp=1789&creative=9325&linkCode=ur2&linkId=de2f901db8833a037c3f0282a2e5fdb5" target="_blank">probiotic supplements</a><img alt="" border="0" height="1" src="//ir-na.amazon-adsystem.com/e/ir?t=cowbochron-20&l=ur2&o=1&camp=1789" style="border: none !important; margin: 0px !important;" width="1" /> in addition to eating probiotic-rich foods.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: white; box-sizing: border-box; color: #231f20; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: 26px; margin: 0px 0px 25px; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit;">To read the full article with the reasons why these things are recommended please visit <a href="https://www.medicalnewstoday.com/articles/322394.php" target="_blank">Medical News Today</a>. </span></div>
</div>
Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-7948986250904084412019-09-06T01:12:00.001-07:002019-09-06T01:30:21.781-07:00New Sjogren's study: Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients<span style="font-family: inherit; font-size: large;"></span><br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-uFfKXVIxFso/XXIUw-2IzjI/AAAAAAAAAlw/ckiyhyBvmb8mgYixGNe-ANqVQbdgzEUCwCLcBGAs/s1600/tread%2Blightly.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="New study of Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients" border="0" data-original-height="1600" data-original-width="1132" height="640" src="https://1.bp.blogspot.com/-uFfKXVIxFso/XXIUw-2IzjI/AAAAAAAAAlw/ckiyhyBvmb8mgYixGNe-ANqVQbdgzEUCwCLcBGAs/s640/tread%2Blightly.jpg" title="Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients" width="451" /></a></div>
<h1 class="wi-article-title article-title-main" style="-webkit-text-stroke-width: 0px; background-color: white; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; font-stretch: inherit; font-style: normal; letter-spacing: normal; line-height: 1.37 !important; margin: 0px 0px 0.1rem; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit; font-size: large;">
<span style="font-family: inherit; font-size: small;"><br /></span></span></h1>
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</span>
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<div style="-webkit-text-stroke-width: 0px; background-color: white; border-image: none; border: 0px; color: #484848; letter-spacing: normal; margin: 0px 0px 24px; orphans: 2; outline: 0px; padding: 0px; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-family: inherit; font-size: large;"><span style="font-family: inherit;"><span style="font-size: small;"><span style="background-color: white; color: #2a2a2a; display: inline; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Sofie L.M. Blokland, Fréderique M. van Vliet-Moret, Maarten R. Hillen, Aridaman Pandit, Roel Goldschmeding, Aike A. Kruize, Gerben Bouma, André van Maurik, Sven Olek, Ulrich Hoffmueller, Joel A.G. van Roon, Timothy R.D.J. Radstake, Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology, </span><em style="-webkit-text-stroke-width: 0px; background-color: white; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; font-stretch: inherit; font-style: italic; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;">Rheumatology</em><span style="background-color: white; color: #2a2a2a; display: inline; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">, Ju</span></span></span><span style="font-family: inherit;"><span style="font-size: small;"><span style="background-color: white; color: #2a2a2a; display: inline; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">ly 2019 </span><a href="https://doi.org/10.1093/rheumatology/kez268" style="-webkit-text-stroke-width: 0px; background-color: white; border-image: none; border: 0px; box-sizing: border-box; color: #006fb7; font-stretch: inherit; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-decoration: none; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;">https://doi.org/10.1093/rheumatology/kez268</a></span></span></span></div>
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<span style="font-family: inherit; font-size: large;"><b>My Understanding of this Study</b> <br /><br />In this study, researchers tested epigenetic cell counting (ECC).<br /><br />ECC is a way of measuring inflammation that may help in diagnosing people with Sjogren's syndrome (SS). It could also help with monitoring symptoms of the disease.<br /><br />The main benefits of epigenetic cell counting are that: </span></div>
<ul>
<li><span style="font-family: inherit; font-size: large;">samples can be stored for longer than other biological molecules. </span></li>
<li><span style="font-family: inherit; font-size: large;">smaller samples are needed. </span></li>
<li><div style="text-align: left;">
<span style="font-family: inherit; font-size: large;">a large amount of cell specific biomarkers can be identified <br /><br />The researchers did ECC on salivary biopsy samples of 57 people with dry mouth including those with primary Sjögren’s syndrome, secondary Sjögren’s syndrome, and some with undiagnosed SS.<br /><br />Using computer algorithms, researchers created patient groups based on the information collected from these salivary cells. This clearly showed the identified types and subsets, some of which were: </span></div>
</li>
<li><div style="text-align: left;">
<span style="font-family: inherit; font-size: large;">people with severe disease who had high amounts of T follicular helper cells </span></div>
</li>
<li><div style="text-align: left;">
<span style="font-family: inherit; font-size: large;">undiagnosed SS samples showing fewer B- and T-cells </span></div>
</li>
<li><div style="text-align: left;">
<span style="font-family: inherit; font-size: large;">patients with SS who had many kindsof cells <br /><br />The study was small and further larger studies are needed to confirm these results and define the best markers that ECC can measure.<br /><br />The researchers suggested that ECC could be used, on its own or in combination with other methods, to “aid in diagnostics, prognostics and monitoring of therapy responses in clinical trials in the future.” </span></div>
</li>
</ul>
<span style="font-family: inherit; font-size: large;"><span style="font-size: small;"><div style="-webkit-text-stroke-width: 0px; background-color: white; border-image: none; border: 0px rgb(72, 72, 72); color: #484848; font-family: Times New Roman; font-size: 16px; font-style: normal; font-variant: normal; letter-spacing: normal; margin: 0px 0px 24px; orphans: 2; outline: 0px; padding: 0px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;">
<span style="font-size: large;"></span></div>
<span style="font-size: large;"></span></span></span><section class="sec" style="-webkit-text-stroke-width: 0px; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; display: block; font-stretch: inherit; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;"><div class="title" style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; line-height: inherit; margin: 0px 0px 0.6rem; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;"><span style="-webkit-text-stroke-width: 0px; background-color: transparent; color: black; display: inline !important; float: none; font-family: inherit; font-size: 24px; font-style: normal; font-variant: normal; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><b>Abstract of Study</b></span></span><br />
<span style="font-family: inherit; font-size: large;"><span style="-webkit-text-stroke-width: 0px; background-color: transparent; color: black; display: inline !important; float: none; font-family: inherit; font-size: 24px; font-style: normal; font-variant: normal; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><b><br /></b></span></span>
<span style="font-family: inherit; font-size: large;"><span style="-webkit-text-stroke-width: 0px; background-color: transparent; color: black; display: inline !important; float: none; font-family: inherit; font-size: 24px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"></span><b>Objective</b></span></div>
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<span style="font-family: inherit; font-size: large;">To investigate whether epigenetic cell counting represents a novel method to quantify immune cells in salivary glands of patients with different forms of Sjögren’s and sicca syndrome and to capture immunopathology and potentially aid in diagnosis.</span></div>
</section><section class="sec" style="-webkit-text-stroke-width: 0px; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; display: block; font-stretch: inherit; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;"><div class="title" style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: bold; line-height: inherit; margin: 1rem 0px 0.6rem; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">Methods</span></div>
<div style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: 1.7em; margin: 0px; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">DNA from frozen salivary gland tissue sections of sicca patients was used for bisulphite conversion of demethylated DNA cytosine residues, followed by cell-specific quantitative PCR to calculate cell percentages in relation to total tissue cell numbers as quantified by housekeeping gene demethylation. The percentages of epigenetically quantified cells were correlated to RNA expression of matched salivary gland tissue and histological and clinical parameters.</span></div>
</section><section class="sec" style="-webkit-text-stroke-width: 0px; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; display: block; font-stretch: inherit; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;"><div class="title" style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: bold; line-height: inherit; margin: 1rem 0px 0.6rem; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">Results</span></div>
<div style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: 1.7em; margin: 0px; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">The percentages of epigenetically quantified CD3, CD4, CD8, T follicular helper (Tfh) cells, FoxP3<sup style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: normal; line-height: inherit; margin: 0px; padding: 0px; position: relative; top: -0.75em; vertical-align: baseline;">+</sup> regulatory T cells and B cells were significantly increased in the salivary glands of patients with SS. Unsupervised clustering using these percentages identified patient subsets with an increased lymphocytic focus score and local B cell hyperactivity and classifies patients different from conventional classification criteria. In particular, Tfh cells were shown to strongly correlate with the expression of CXCL13, lymphocytic focus scores, local B cell hyperactivity and anti-SSA positivity.</span></div>
</section><section class="sec" style="-webkit-text-stroke-width: 0px; border-image: none; border: 0px; box-sizing: border-box; color: #2a2a2a; display: block; font-stretch: inherit; font-style: normal; font-weight: 400; letter-spacing: normal; line-height: inherit; margin: 0px; orphans: 2; padding: 0px; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: 2; word-spacing: 0px;"><div class="title" style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: bold; line-height: inherit; margin: 1rem 0px 0.6rem; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">Conclusion</span></div>
<div style="border-image: none; border: 0px; box-sizing: border-box; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: 1.7em; margin: 0px; padding: 0px; vertical-align: baseline;">
<span style="font-family: inherit; font-size: large;">Epigenetic cell counting is a promising novel tool to objectively and easily quantify immune cells in the labial salivary gland of sicca patients, with a relatively small amount of tissue needed. In view of the potential of this technique to include a huge number of (cell-specific) biomarkers, this opens up new standardized ways of salivary gland analysis with high relevance for patient classification, understanding of immunopathology and monitoring of drug responses in clinical trials.</span></div>
</section>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-24478355219744993952019-08-26T01:56:00.000-07:002019-09-18T03:28:31.880-07:00Sjögren's syndrome affects more than exocrine glands!<div class="separator" style="clear: both; text-align: center;">
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<a href="https://1.bp.blogspot.com/-BmHVWGYYVVc/XYIGRwctAFI/AAAAAAAAAmg/qFemx05Dc7k2oJ53XZR6FIx6hgl9VvPHwCLcBGAsYHQ/s1600/Sjogren%2527s%2BBlog.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="810" data-original-width="540" height="640" src="https://1.bp.blogspot.com/-BmHVWGYYVVc/XYIGRwctAFI/AAAAAAAAAmg/qFemx05Dc7k2oJ53XZR6FIx6hgl9VvPHwCLcBGAsYHQ/s640/Sjogren%2527s%2BBlog.jpg" width="425" /></a></div>
<span style="font-size: large;">Sjögren's syndrome (SS) is a common immune disease that mainly</span><br />
<span style="font-size: large;"> affects the exocrine glands. That's what we usually read! But we sufferers know that it affects many, many other parts of the body.</span><br />
<span style="font-size: large;"><br /></span>
<span style="font-size: large;">What exactly though is an exocrine gland? These are glands that secrete a substance out through a duct. They include the salivary glands, sweat glands and glands within the gastrointestinal tract, which is the stomach and intestines. <span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">The exocrine glands are the "glands of external secretion." </span>(<span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">medicinenet)</span></span><br />
<span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-size: large;"><br /></span></span></span>
<span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-family: sans-serif; font-style: normal; font-variant: normal; font-weight: 700; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;">Xerostomia </span></span>is the medical term for dry mouth. But it is so much more:</span></span></span><br />
<ul>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> reduced saliva </span></span></span></li>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">tooth decay </span></span></span></li>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">dental erosion </span></span></span></li>
<li><span style="font-family: inherit; font-size: large;">d<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">ifficulty wearing </span>dentures</span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><span style="font-size: large;">oral thrush <span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> </span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><span style="font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">altered taste sensation</span><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> </span></span></span></span></span></li>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">altered sense of smell </span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;">burning or tingling sensation in the mouth</span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-size: large;">deep grooves in tongue</span> <span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"></span></span></span></span></span></li>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">difficulty swallowing and chewing </span></span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><span style="font-size: large;">d<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">ry, sore, and cracked lips and corners of the mouth </span></span></span></span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><span style="font-size: large;">m<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">outh soreness </span></span></span></span></span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"></span></span></span></span></span></span></span><span style="font-family: inherit; font-size: large;">dry throat </span></li>
<li><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">dry cough </span></span></span></li>
</ul>
<span style="font-size: large;"><b><span style="font-family: inherit;">K</span></b><span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-family: "times new roman"; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><b>eratoconjuctivitis sicca</b></span><span style="font-family: inherit;"> <span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">is the condition of having </span>dry<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> </span>eyes. </span><span style="font-family: inherit;">S<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">ymptoms include:</span></span></span></span></span><br />
<ul>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">eye irritation </span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">redness </span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">discharge</span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">easily fatigued eyes</span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">blurred vision </span></span></span></span></li>
<li><span style="font-size: large;"><span style="font-family: inherit;">s<span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">carring of the </span>cornea<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> may occur without treatment</span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">pressure behind the eye</span></span></span></span></span></li>
<li><span style="background-color: transparent; color: black; display: inline; float: none; font-variant: normal; letter-spacing: normal; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit; font-size: large;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 22.28px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">excess tearing</span></span></span></span></span></li>
<span style="font-size: large;"><b></b></span></ul>
<div>
<span style="font-size: large;">SS can involve many other organs including:</span><span style="font-size: large;"></span></div>
<ul>
<li><span style="font-size: large;">lung (interstitial lung disease)</span></li>
<li><span style="font-size: large;">kidney (renal tubular acidosis and hypokalemia)</span></li>
<li><span style="font-size: large;">nerve (peripheral neuropathy) </span></li>
<li><span style="font-size: large;">vessel (vasculitis, Raynaud's phenomenon)</span></li>
<li><span style="font-size: large;">bladder (interstitial cystitis) </span></li>
<li><span style="font-size: large;">lymph node (lymphadenopathy)</span></li>
<li><span style="font-size: large;">liver (autoimmune hepatitis)</span></li>
<li><span style="font-size: large;">pancreas (pancreatitis) </span></li>
<li><span style="font-size: large;">GI (reflux esophagitis, peptic ulcer)</span></li>
</ul>
<div class="separator" style="clear: both; text-align: center;">
</div>
<ul>
</ul>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-xmLSjhOzfrE/XXgfBCE6iFI/AAAAAAAAAmE/NLe97CJzH_gPeuZyi0NfcucTNmJdJNJNACEwYBhgL/s1600/1SjS%2Bconnect%2B%25283%2529.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="315" data-original-width="560" height="225" src="https://1.bp.blogspot.com/-xmLSjhOzfrE/XXgfBCE6iFI/AAAAAAAAAmE/NLe97CJzH_gPeuZyi0NfcucTNmJdJNJNACEwYBhgL/s400/1SjS%2Bconnect%2B%25283%2529.png" width="400" /></a></div>
<span style="font-size: xx-small;"></span><span style="font-size: large;"></span><span style="color: #004000; font-family: "arial";"><br /></span>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-7201180029043946532019-07-19T23:11:00.000-07:002019-10-01T23:27:24.843-07:00EULAR Sjögren's syndrome disease activity index (ESSDAI) <div class="separator" style="clear: both; text-align: center;">
</div>
<div class="separator" style="clear: both; text-align: center;">
</div>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-c51zWooQQsA/XZQ_ViuanPI/AAAAAAAAAno/lcCGKMrVPd4jyjBXdvbCSZHblpRYE_CgwCLcBGAsYHQ/s1600/Sjogren%2527s%2BBlog%2B%25284%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="what is EULAR Sjögren's syndrome disease activity index " border="0" data-original-height="810" data-original-width="540" height="640" src="https://1.bp.blogspot.com/-c51zWooQQsA/XZQ_ViuanPI/AAAAAAAAAno/lcCGKMrVPd4jyjBXdvbCSZHblpRYE_CgwCLcBGAsYHQ/s640/Sjogren%2527s%2BBlog%2B%25284%2529.jpg" title="EULAR Sjögren's syndrome disease activity index (ESSDAI)" width="426" /></a></div>
<span style="background-color: transparent; color: #333333; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 25px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;">The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. </span></span><br />
<span style="font-family: inherit;"><br /></span>
<span style="font-family: inherit;">It<span style="background-color: transparent; color: #333333; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 25px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure in current randomised clinical trials.</span></span><br />
<div>
<span style="font-family: inherit;"><span style="background-color: transparent; color: #333333; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 25px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><br /></span></span></div>
<div>
<span style="color: #001000;">The ESSDAI is a systemic disease activity index that was created in 2009. It was developed by consensus of a large group of worldwide experts from European and North American countries, supported by the EULAR. </span><span style="color: #001000; font-family: inherit;"><span style="background-color: transparent; color: black; direction: ltr; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 300; letter-spacing: normal; line-height: 22.66px; text-align: justify; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">The European League Against Rheumatism (EULAR) is the organisation which represents the people with arthritis/rheumatism, health professionals and scientific societies of rheumatology of all the European nations.</span></span></div>
<div>
<span style="color: #001000;"><span style="background-color: transparent; color: #001000; display: inline; float: none; font-family: "times new roman"; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><br /></span></span></div>
<div>
<span style="color: #001000;"><span style="background-color: transparent; color: #001000; display: inline; float: none; font-family: "times new roman"; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">The ESSDAI</span> includes 12 domains (ie, organ systems: cutaneous, respiratory, renal, articular, muscular, peripheral nervous system (PNS), central nervous system (CNS), haematological, glandular, constitutional, lymphadenopathic, biological). </span></div>
<div>
<span style="color: #001000;"><br /></span></div>
<div>
<span style="color: #001000;">The ESSDAI includes organ-by organ definitions that were agreed on by a large number of experts. </span></div>
<div>
<span style="color: #001000;"><br /></span></div>
<div>
<span style="color: #001000;">Each domain is divided into 3–4 levels of activity. Definition of each activity level is provided by a detailed description of what should be considered in that item. </span></div>
<div>
<span style="color: #001000;"><br /></span></div>
<div>
<span style="color: #001000;">The aim was to obtain a standardised instrument for the evaluation of systemic activity in order for the ESSDAI to be used as outcome criteria to evaluate primary SS in clinical trials as well as daily practice. </span></div>
<div>
<span style="color: #001000;"><br /></span></div>
<div>
<span style="color: #001000;">This tool has been validated in a large independent cohort and has been shown to have a high contentvalidity, to be highly reproducible and to be able to detect change.</span></div>
<span style="color: #001000;"></span><br />
<div>
<span style="color: #001000;"><br /></span></div>
<span style="color: #001000;">
<div>
This information is OPEN ACCESS from Seror R, Bowman SJ, Brito-Zeron P, et al. EULAR Sjögren’s syndrome disease activity index (ESSDAI): a user guide. RMD Open 2015;1:e000022. doi:<a href="https://rmdopen.bmj.com/content/rmdopen/1/1/e000022.full.pdf">10.1136/rmdopen-2014000022</a></div>
<div>
<u><span style="color: #000120;"></span></u><br /></div>
</span><span style="color: #001000;"></span><b></b><i></i><u></u><sub></sub><sup></sup><strike></strike><span style="font-family: inherit;"></span>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-53912872907928987602015-07-29T23:43:00.002-07:002019-09-18T03:37:38.641-07:00New evidence in treating eye dryness in Sjogren's Syndrome<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-l-hdCN8EHdA/XYIH_xsmm5I/AAAAAAAAAms/maBiXxcaCeMz3ESw4p3fH4ORVZkBaidpwCLcBGAsYHQ/s1600/Sjogren%2527s%2BBlog%2B%25281%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="evidence in treating eye dryness in Sjogren's Syndrome" border="0" data-original-height="810" data-original-width="540" height="640" src="https://1.bp.blogspot.com/-l-hdCN8EHdA/XYIH_xsmm5I/AAAAAAAAAms/maBiXxcaCeMz3ESw4p3fH4ORVZkBaidpwCLcBGAsYHQ/s640/Sjogren%2527s%2BBlog%2B%25281%2529.jpg" title="New evidence in treating eye dryness in Sjogren's Syndrome" width="426" /></a></div>
<span style="font-size: small;"><span style="font-family: inherit;"><br /></span></span>
<span style="font-size: small;"><span style="font-family: inherit;">Emerging evidence suggests that B cell and co-stimulatory targeted therapy may be used in the future to treat eye dryness symptoms in Sjogren's Syndrome.</span></span><br />
<span style="color: red;"><span style="color: black;">Recent
developments in the understanding of SS show that eye dryness is associated with:</span></span><br />
<ul>
<li><span style="color: red;"><span style="color: black;">dysfunction of the lacrimal glands </span></span></li>
<li>changes in the
tear composition</li>
<li>abnormalities in <span style="color: red;"><span style="color: black;"><span class="oneClick-link"></span><span class="oneClick-link oneClick-available">chemicals</span> <span class="oneClick-link oneClick-available">secreted</span> <span class="oneClick-link">by</span><span class="oneClick-link"></span> <span class="oneClick-link oneClick-available">nerve</span> <span class="oneClick-link oneClick-available">cells </span></span></span></li>
</ul>
<span style="color: red;"></span><span style="color: red;"><span style="color: black;">"There is good evidence for the use of
topical artificial tears, antiinflammatories and <a href="http://www.nlm.nih.gov/medlineplus/druginfo/meds/a601207.html" target="_blank">Cyclosporine,</a> and oral
<a href="http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608039.html" target="_blank">Pilocarpine</a> and <a href="http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608025.html" target="_blank">Cevimeline</a> in controlling the symptoms of ocular dryness
associated with SS." See Reference below.</span></span><br />
<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="background-color: transparent; color: black; font-family: "times new roman"; font-size: 16px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; margin-bottom: 8px; margin-left: auto; margin-right: auto; padding: 6px; text-align: center; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><tbody style="margin-bottom: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">
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<a href="http://1.bp.blogspot.com/-gqj6eMCMzUY/VbnG_fj3dgI/AAAAAAAAAik/-k6thVuOBO8/s1600/download-picture.php.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="eye dryness in Sjogren's Syndrome" border="0" height="171" src="https://1.bp.blogspot.com/-gqj6eMCMzUY/VbnG_fj3dgI/AAAAAAAAAik/-k6thVuOBO8/s400/download-picture.php.jpg" title="New evidence in treating eye dryness in Sjogren's Syndrome" width="400" /></a></div>
</td></tr>
<tr style="margin-bottom: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"><td class="tr-caption" style="font-size: 12.8px; padding-top: 4px; text-align: center;"></td></tr>
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<h4>
CONCLUSIONS OF THE RESEARCH: Conventional<span style="font-weight: normal;"><a href="http://sjogrenssyndrome.blogspot.com.au/2015/07/what-are-dmards.html" target="_blank"> DMARDs</a> are not particularly effective in treating the symptoms of dryness in the eyes in Sjogren's Syndrome (SS). These drugs are commonly prescribed for SS. Emerging evidence suggests that B cell and
co-stimulatory targeted therapy may play a role in the future.</span></h4>
<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-mgqTK2uGqpU/VbnFSKR-22I/AAAAAAAAAiQ/oYy0HI-dqbQ/s1600/B_cell_activation.svg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" height="400" src="https://4.bp.blogspot.com/-mgqTK2uGqpU/VbnFSKR-22I/AAAAAAAAAiQ/oYy0HI-dqbQ/s400/B_cell_activation.svg" width="260" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;"><span class="mw-mmv-filename-prefix"></span><span class="mw-mmv-filename">B cell activation</span></td></tr>
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<br /><span style="font-family: inherit;">B cell depletion has been associated with improvement in many (but not all) conditions associated with autoantibody production.<br /><br />B cell targeted therapy for rheumatoid arthritis (RA) was developed with the objective of removing B cell clones responsible for the production of pathogenic autoantibodies. [<a href="http://www.uptodate.com/contents/rituximab-and-other-b-cell-targeted-therapies-for-rheumatoid-arthritis/abstract/1">1</a>]. This has not been achieved yet but B cell depletion therapy has been found to have a major impact on RA in the short term.<br /><br />This post is my attempts to simplify medical research into Sjogren's Syndrome so that people with SS can understand: Here is the REFERENCE: Advances in the treatment of ocular dryness associated with Sjögren׳s syndrome. <a href="http://www.ncbi.nlm.nih.gov/pubmed/26216545">PubMed June 2015</a> Ciurtin C, Ostas A, Cojocaru VM, Walsh SB, Isenberg DA.<br /><br /><a href="http://sjogrenssyndrome.blogspot.com.au/2015/07/what-are-dmards.html">Find out more about DMARD's</a>: what they are and specific ones. </span><div class="auths">
<span style="font-size: xx-small;"></span></div>
Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com10tag:blogger.com,1999:blog-480140972539070676.post-10998708342303597262015-07-29T15:43:00.001-07:002015-07-29T15:47:57.756-07:00What are DMARDs?<div class="node">
<span style="background-color: white;"><span style="background-color: white;"><span style="background-color: white;"><span style="background-color: white;">DMARDs</span></span> are disease-modifying anti rheumatic drugs. In layman language - drugs that help with rheumatic diseases, including <a href="http://rheumatoidarthritisstories.blogspot.com.au/search/label/Arthritis%20Resources" target="_blank">rheumatoid arthritis (RA)</a>, <a href="http://www.webmd.com/back-pain/guide/ankylosing-spondylitis">ankylosing spondylitis</a>, and <a href="http://www.webmd.com/osteoarthritis/psoriatic-arthritis">psoriatic arthritis</a> and Sjogren's Syndrome.</span>
</span></div>
<div class="node">
These drugs not only treat arthriti<span style="background-color: white;">s symptoms of inflammation, but they also can slow down progressive joint destruction.</span></div>
<div class="node">
<br /></div>
<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-Qh0ajBrkr6s/VblWN9BEe7I/AAAAAAAAAiA/ywdREyIcfV8/s1600/Imuran_2.JPG" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="DMARDs" border="0" height="300" src="http://1.bp.blogspot.com/-Qh0ajBrkr6s/VblWN9BEe7I/AAAAAAAAAiA/ywdREyIcfV8/s400/Imuran_2.JPG" title="What are DMARDs?" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Azathioprine tablets, taken by <a class="new" href="https://en.wikipedia.org/w/index.php?title=User:Samir_%28The_Scope%29&action=edit&redlink=1" title="User:Samir (The Scope) (page does not exist)">Samir</a></td></tr>
</tbody></table>
<div class="node">
<br /></div>
<div class="node">
<span style="background-color: white;">DMARDs include:</span>
</div>
<ul class="node">
<li>
<span style="background-color: white;">
Azathioprine<a href="https://www.blogger.com/null"> (Imuran)</a></span>
</li>
<li>
<span style="background-color: white;">Biologics (Actemra, Cimzia, Enbrel, Humira, Kineret, Orencia, Remicade, Rituxan, Simponi)</span>
</li>
<li>
<span style="background-color: white;">
Cyclophosphamide (Cytoxan)</span>
</li>
<li>
<span style="background-color: white;">
Cyclosporine (Neoral)</span>
</li>
<li>
Hydroxychloroquine<a href="https://www.blogger.com/null"> (Plaquenil)</a></li>
<li>
<span style="background-color: white;">
Leflunomide (Arava)</span>
</li>
<li>
<span style="background-color: white;">
Methotrexate (Rheumatrex, Trexall)</span>
</li>
<li>
<span style="background-color: white;">
Sulfasalazine (Azulfidine)</span>
</li>
<li>Tofacitinib (Xeljanz)</li>
</ul>
RESOURCES: <br />
<a class="jawsonly" href="http://www.webmd.com/rheumatoid-arthritis/modifying-medications#mainContentContainer_area"> </a><br />
<div id="logo">
<a href="http://www.webmd.com/www/default.htm"><img alt="WebMD: Better information. Better health." class="logo_rdr" src="http://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/usability/2012/LBi_Masthead/logo_trans.png" /></a></div>
http://www.webmd.com/rheumatoid-arthritis/modifying-medicationsLee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com1tag:blogger.com,1999:blog-480140972539070676.post-70498745086357887092015-05-03T21:41:00.001-07:002015-05-03T21:45:10.306-07:00Fact of the week: Sjogren's syndrome often accompanies other immune system diseases<div class="separator" style="clear: both; text-align: center;">
<a href="http://1.bp.blogspot.com/-kWjTCMgel-w/VUbupUGzpsI/AAAAAAAAAhs/19nYa9qtumI/s1600/ss%2Bwater%2Bquote.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Sjogren’s syndrome and other immune-system disorders" border="0" src="http://1.bp.blogspot.com/-kWjTCMgel-w/VUbupUGzpsI/AAAAAAAAAhs/19nYa9qtumI/s1600/ss%2Bwater%2Bquote.jpg" title="Sjogren’s syndrome often accompanies other immune-system disorders" /></a></div>
<br />
Sjogren’s syndrome often accompanies other immune-system disorders, such as rheumatoid arthritis and lupus and hashimoto's thyroid.<br />
<br />
We did a small informal <a href="https://www.facebook.com/permalink.php?story_fbid=946988678679629&id=233053606739810" target="_blank">survey on facebook</a> asking Sjogren's sufferers if they had other autoimmune conditions as well as Sjogren's. Seventeen women responded. This is what they said:<br />
4 had Hashimoto's thyroiditis, an underactive thyroid condition.<br />
1 had Graves disease, an overactive thyroid condition.<br />
3 had a type of myositis.<br />
4 had Rheumatoid Arthritis RA.<br />
3 had Lupus.<br />
2 had Celiac disease.<br />
1 had Diabetes.<br />
2 had Scleroderma.<br />
1 had Ankolysing Spondylitis AS. <br />
6 had Raynaud's disease.<br />
<br />
6 women had 3 or more autoimmune conditions. Some mentioned other conditions that were not immune related diseases.<br />
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<br />Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com7tag:blogger.com,1999:blog-480140972539070676.post-33847987622050655272015-04-25T01:51:00.001-07:002019-09-18T05:09:12.419-07:00Thoughts on gluten free diet and Sjogren's Syndrome<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
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<span style="font-family: inherit;"><span style="color: black;">Here you will find an<span style="font-family: inherit;"><span style="-webkit-text-stroke-width: 0px; background-color: white; display: inline !important; float: none; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"> interesting case history published in the Journal of Gluten Sensitivity • Autumn 2011 and at the bottom some links to gluten free recipes. </span></span></span></span><br />
<span style="color: black; font-family: inherit;"><span style="-webkit-text-stroke-width: 0px; background-color: white; color: #59626a; display: inline !important; float: none; font-family: "Open Sans",Helvetica,Arial,sans-serif; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"><br /></span></span>
<span style="font-family: inherit;"><span style="-webkit-text-stroke-width: 0px; background-color: white; color: #59626a; display: inline !important; float: none; font-family: "Open Sans",Helvetica,Arial,sans-serif; font-style: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: pre-wrap; widows: 2; word-spacing: 0px;"></span>The following is a patient case history from the clinic of Alexander R. Shikhman, MD, PhD, FACR : </span><br />
<span style="font-family: inherit;"><i><br /></i></span>
<span style="font-family: inherit;"><i>A 28 year old woman was seen in our clinic due to her complaints of longstanding irritable bowel syndrome and recent onset of eye dryness. Her initial presentation included abdominal pain, bloating and irregular bowel movements. She was seen by several gastroenterologists and underwent several upper endoscopies and colonoscopies with mucosal biopsies which were non-diagnostic. Her lab test results showed positive IgG antigliadin antibodies and she was told that "this is a common finding among healthy people, and is not indicative of any illnesses." She was seen by her ophthalmologist and prescribed with contact lenses which she could not wear due to significant eye discomfort and irritation. Further eye examination showed that she had diminished tear production and was referred to our clinic to rule out Sjogren's syndrome. </i></span><br />
<span style="font-family: inherit;"><i></i></span><span style="font-family: inherit;"><i><br />Upon physical examination in our clinic the patient not only demonstrated profound eye dryness but also showed evidence of dry mouth, fissured tongue and patchy areas ofthrush as well as very dry skin. A sonographic evaluation of her major salivary glands was suspicious for moderately advanced Sjogren's syndrome. Her laboratory test results showed: positive anti-SSAI Ro antibodies, elevated serum immunoglobulin G, low neutrophil count as well as low levels of vitamin D and fenitin (a serum marker of iron storage state). Also, the patient was found to have positive serum IgG and salivary IgA anti-gliadin antibodies as well as positive HLA 002 (a molecular marker associated with gluten intolerance). </i></span><br />
<span style="font-family: inherit;"><i></i></span><span style="font-family: inherit;"><i><br />Based on a combination of clinical history, physical findings and laboratory test results, the patient was diagnosed with gluten intolerance and Sjogren's syndrome. In addition to the aforementioned tests, the patient underwent food intolerance testing based on serum IgG4 antibodies which showed not only gluten but also cow's casein intolerance. Her treatment options included a traditional route of therapy based on drugs or an integrative approach based on dietary modifications and food supplements. <b>She opted for the integrative approach and started a gluten-free and dairy-free diet as well as iron glycinate, vitamin D, specific probiotics and digestive enzymes. </b></i></span><br />
<span style="font-family: inherit;"><i><b></b><br />After the first month on the diet and supplements, she reported a remarkable improvement of her irritable bowel symptoms and in three months, she started noticing an improvement of the dryness. Laboratory tests performed six months after initiation of the therapy showed normalization of the IgG level, disappearance of anti-SSA/Ro antibodies and a slightly suppressed neutrophil count. Through following the prescribed diet and supplements she is now symptom free. </i></span><br />
<i></i><br />
<a href="http://www.glutenfreeforgood.com/blog/" target="_blank">Melissa at gluten free for good</a> has great recipes and wisdom if you are following this dietary path. <br />
<br />
<blockquote class="tr_bq">
Melissa says "<em>The gluten-free diet is the medical protocol for celiac disease. Why not for all autoimmune diseases? Gluten causes inflammation. Decreasing inflammation via diet and lifestyle should be the first step in reducing the impact of the disease, so it makes sense to eliminate gluten.</em></blockquote>
<div>
<blockquote class="tr_bq">
<i>Right?</i></blockquote>
</div>
<div>
<blockquote class="tr_bq">
<i>Apparently <a href="http://sjogrenssyndrome.blogspot.com.au/2011/10/venus-williams-about-sjogrens.html" target="_blank">Venus</a> is on a vegan diet to combat her symptoms. There are rumors she’s dabbling in the gluten-free diet as well."</i></blockquote>
</div>
<i></i><br />
Melissa is author of <a href="http://www.amazon.com/gp/product/161519052X/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=161519052X&linkCode=as2&tag=cowbochron-20&linkId=B4HACABVJDAZXMXP">The Gluten-Free Edge</a><img alt="" border="0" height="1" src="https://ir-na.amazon-adsystem.com/e/ir?t=cowbochron-20&l=as2&o=1&a=161519052X" style="border: none !important; margin: 0px !important;" width="1" /><br />
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<a href="http://4.bp.blogspot.com/-oU96kjRwshY/VTtTatwnHtI/AAAAAAAAAhY/nYIBdNkQdmU/s1600/gluten-free-101-Roasted-Salmon-682x1024.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="more on gluten free and Sjogren's Syndrome" border="0" height="400" src="https://4.bp.blogspot.com/-oU96kjRwshY/VTtTatwnHtI/AAAAAAAAAhY/nYIBdNkQdmU/s1600/gluten-free-101-Roasted-Salmon-682x1024.jpg" style="cursor: move;" title="gluten free and Sjogren's Syndrome" width="266" /></a></div>
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one-pot roasted salmon, rice and vegetables</div>
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Do you have Sjögren’s and celiac disease or celiac intolerance?<br />
What do you think? Should people with autoimmune conditions follow a gluten-free diet?<br />
Have you tried a gluten free diet to help your Sjögren’s Syndrome?Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com11tag:blogger.com,1999:blog-480140972539070676.post-86593130552540044762015-04-12T18:48:00.002-07:002015-04-15T04:12:49.466-07:00Please join in my Sjogren's book giveaway <br />
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Books will be mailed to you free of charge from Amazon.Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com10tag:blogger.com,1999:blog-480140972539070676.post-18478038739801005562015-04-01T23:46:00.000-07:002015-04-13T00:22:13.992-07:00Join in with us for Sjogren's Awareness month this April<div class="separator" style="clear: both; text-align: center;">
<a href="http://3.bp.blogspot.com/-pB-1imdsAtE/VStpozaLqhI/AAAAAAAAAf0/tW2OEmkor0Y/s1600/april-is-for-sjogren-s-awareness.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Sjogren's Awareness month is April" border="0" src="http://3.bp.blogspot.com/-pB-1imdsAtE/VStpozaLqhI/AAAAAAAAAf0/tW2OEmkor0Y/s1600/april-is-for-sjogren-s-awareness.png" height="320" title="Sjogren's Awareness month this April" width="240" /></a></div>
<br />
What can you do to help spread Sjogren's Awareness?<br />
If you are on <strong><a href="https://www.facebook.com/pages/Sjogrens-blog/233053606739810?ref=hl" target="_blank">facebook</a></strong> please join us there for giveaways, games and information about Sjogren's that you can share. There will also be many opportunities for you to share your story.<br />
<br />
If you are on PINTEREST maybe you could share some of our blog posts.<br />
If you are on twitter please share some of our posts.<br />
Helping others hear about Sjogren's Syndrome and understand about it is the beginning of community awareness and the first step in getting more research into the disease.Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com1tag:blogger.com,1999:blog-480140972539070676.post-51887280612133216362015-03-05T21:06:00.000-08:002015-04-12T21:28:11.104-07:00Personal stories about Sjogren's Syndrome<div class="separator" style="clear: both; text-align: center;">
<a href="http://4.bp.blogspot.com/-PvcvMI0ITSQ/VStFziXz2bI/AAAAAAAAAfk/GCQo0rmFDlQ/s1600/imagesB2W2SUKH2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="http://4.bp.blogspot.com/-PvcvMI0ITSQ/VStFziXz2bI/AAAAAAAAAfk/GCQo0rmFDlQ/s1600/imagesB2W2SUKH2.jpg" height="218" width="320" /></a></div>
<div class="separator" style="clear: both; text-align: center;">
<br /></div>
This was posted on the blog and we get so many stories here I thought it would be very worthwhile to share some of them:<br />
<br />
<em>I was diagnosed at the age of 2, very uncommon, and I am now 24. </em><br />
<em>The past couple years I have been developing more problems and discovering different symptoms connected with my SS. </em><br />
<em>Last year I had a lung biopsy and am now taking an inhaler as needed. I started seeing my Rheumatoid specialist at the age of 14 and it was discovered that I had rheumatoid fluid in all my joints. The fluid has decreased but pain is reoccurring. </em><br />
<em></em><br />
<em>The most common symptoms I have are: chronic arthritic pain as well as inflammation in my periodic/salivary glands. I have changed my diet and am now trying to be gluten free. Gluten causes inflammation, which SS can tend to be associated with. I have only been <a href="http://sjogrenssyndrome.blogspot.com.au/2012/08/gluten-and-sjogrens.html" target="_blank"><strong>gluten free</strong></a> for a few months, however, I do see a difference in how I feel overall. <br /><br />I am glad I discovered this blog. I find it interesting reading other's experience with SS since I've never met anyone else with this disorder considering it is very rare at my age.</em>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com2tag:blogger.com,1999:blog-480140972539070676.post-6058615898251909382013-09-19T22:21:00.000-07:002019-09-18T05:46:39.450-07:00Celebrities with Sjogren's Syndrome<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-I9t47v_Ji3s/UXiy1mrCLJI/AAAAAAAAAcg/KqavlKEi2m4/s1600/Nina+Rawls,+and+LP.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="celebrities with Sjogren's syndrome" border="0" src="https://4.bp.blogspot.com/-I9t47v_Ji3s/UXiy1mrCLJI/AAAAAAAAAcg/KqavlKEi2m4/s1600/Nina+Rawls,+and+LP.jpg" title="Nina Rawls" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Nina Rawls</td></tr>
</tbody></table>
Here Nina Rawls, who is widow of singer Lou Rawls, reveals her fight with Sjogren’s
Syndrome.<br />
<br />
Nina Rawls has Secondary Sjogren’s Syndrome, meaning it occurs in the presence of another
connective tissue autoimmune disease, in her case it is lupus,also known as SLE<br />
<br />
<blockquote class="tr_bq">
“<em>With my finding, I am now an advocate for Sjogren’s syndrome awareness, early
diagnosis and treatment. </em> </blockquote>
<blockquote class="tr_bq">
<em>I’m learning that although there is no cure for the
syndrome, there are treatments that can greatly improve my troubling symptoms
and will prevent further complications,”</em> concludes Rawls.<em> </em> </blockquote>
<blockquote class="tr_bq">
<em>“I’m hoping a greater
awareness of the syndrome will push others to be more pro-active in talking with
their doctors and dentists about their symptoms and gain potential treatment
options</em>.”</blockquote>
<br />
<br />
From PR Web where you can <a href="http://www.prweb.com/releases/2011/9/prweb8786365.htm" target="_blank">read the full story</a>.<br />
<br />
Read more about <a href="http://sjogrenssyndrome.blogspot.com.au/2013/03/do-i-have-primary-or-secondary-sjogrens.html" target="_blank">Secondary and Primary Sjogren’s Syndrome</a>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com5tag:blogger.com,1999:blog-480140972539070676.post-87130990997626253292013-06-25T05:41:00.000-07:002013-09-19T21:45:50.626-07:00Sjogren's Fact of the Week<div _mce_tmp="1">
<div class="separator" style="clear: both; text-align: center;">
<a href="http://2.bp.blogspot.com/-KCKuUJxDc58/UjvSHXC0ErI/AAAAAAAAAdg/x9M33URuGj4/s1600/SS+women+hug.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="160" src="http://2.bp.blogspot.com/-KCKuUJxDc58/UjvSHXC0ErI/AAAAAAAAAdg/x9M33URuGj4/s200/SS+women+hug.jpg" width="200" /></a></div>
<span _mce_style="font-family: tahoma,arial,helvetica,sans-serif;" style="font-family: tahoma,arial,helvetica,sans-serif;"><span _mce_style="font-size: medium;" style="font-size: medium;"></span></span><span _mce_style="font-family: tahoma,arial,helvetica,sans-serif;" style="font-family: tahoma,arial,helvetica,sans-serif;"><span _mce_style="font-size: medium;" style="font-size: medium;"></span></span><br /></div>
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<div class="fontblack80arial">
90 percent of those who get Sjögren's Syndrome are women. <strong><a _mce_href="http://sjogrenssyndrome.blogspot.com/2011/04/who-gets-sjogrens-syndrome.html" href="http://sjogrenssyndrome.blogspot.com/2011/04/who-gets-sjogrens-syndrome.html" target="_blank" title="Read more.">Read
more<span _mce_style="font-family: tahoma,arial,helvetica,sans-serif;" style="font-family: tahoma,arial,helvetica,sans-serif;"><span _mce_style="font-size: medium;" style="font-size: medium;"></span></span></a></strong></div>
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<span _mce_style="font-family: tahoma,arial,helvetica,sans-serif;" style="font-family: tahoma,arial,helvetica,sans-serif;"><span _mce_style="font-size: medium;" style="font-size: medium;"><strong></strong></span></span> </div>
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Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com1tag:blogger.com,1999:blog-480140972539070676.post-52305492910267282072013-06-05T22:17:00.002-07:002013-06-05T22:23:29.892-07:00Primary Sjögren's syndrome sufferers prone to develop serious complications<div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;">I did not like the results of this study and found it quite depressing.</span></div>
<div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<em><span style="font-family: Arial, Helvetica, sans-serif;">Patients with primary Sjögren's syndrome are prone to develop serious complications over the long term, despite the presumption that this is a relatively benign autoimmune disease, a 25-year review found.</span></em></div>
<div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<em><span style="font-family: Arial, Helvetica, sans-serif;">For instance, fully half developed an additional autoimmune disease such as cutaneous lupus, and one in every 10 was diagnosed with non-Hodgkin's lymphoma, according to Esha Abrol, BSc, of University College London.</span></em><br />
<em><span style="font-family: Arial, Helvetica, sans-serif;"></span></em> </div>
<div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;">The study was of only152 patients but they had been studied since 1986. There were other important facts that came out of this study as well:</span></div>
<ul><span style="font-family: Arial, Helvetica, sans-serif;">
</span>
<li><div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;">one quarter of the patients had nervous system involvement and peripheral neuropathy</span></div>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span></li>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span>
<li><div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;">18.5% of patients had died at an average age of 72, which is 10 years earlier than the average life expectancy of a woman un the UK</span></div>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span></li>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span>
<li><div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;">the most common disease was non- Hodgkin's lymphoma</span></div>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span></li>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span></ul>
<span style="-webkit-text-stroke-width: 0px; background-color: white; color: #333333; display: inline !important; float: none; font-family: Arial, Helvetica, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"></span><div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="-webkit-text-stroke-width: 0px; background-color: white; color: #333333; display: inline !important; float: none; font-family: Arial, Helvetica, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">I am not sure what can be done about this except to enjoy life while we have it and have regular check ups by a specialist in Sjogren's Syndrome.</span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; color: #333333; display: inline !important; float: none; font-family: Arial, Helvetica, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"></span><br />
<span style="-webkit-text-stroke-width: 0px; background-color: white; color: #333333; display: inline !important; float: none; font-family: Arial, Helvetica, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Do you feel that you have a good specialist who understands all this?</span></div>
<span style="-webkit-text-stroke-width: 0px; background-color: white; color: #333333; display: inline !important; float: none; font-family: Arial, Helvetica, sans-serif; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
</span><div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
<span style="font-family: Arial, Helvetica, sans-serif;"></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Read the full report from </span><a href="http://www.medpagetoday.com/MeetingCoverage/BSR/38713" target="_blank"><span style="font-family: Arial, Helvetica, sans-serif;">Medpage</span></a>. <span style="font-family: Arial, Helvetica, sans-serif;">Maybe we should be printing it out and taking it to our specialists.</span></div>
<span style="font-family: Arial, Helvetica, sans-serif;">
</span><br />
<div style="-webkit-text-stroke-width: 0px; background-color: transparent; border: 0px currentColor; color: #333333; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 20px; margin: 0px 0px 15px; outline: 0px; padding: 0px; text-align: left; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; word-spacing: 0px;">
</div>
Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com2tag:blogger.com,1999:blog-480140972539070676.post-50536489244484781212013-04-24T18:21:00.002-07:002013-09-19T21:46:14.510-07:00Sjogren's Fact of the Week<div class="separator" style="clear: both; text-align: center;">
<a href="http://1.bp.blogspot.com/-C13X3NTMBKg/UXiE7KOFDqI/AAAAAAAAAcQ/ESRKpfZ4Gus/s1600/849-1234251683JKYT.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="217" src="http://1.bp.blogspot.com/-C13X3NTMBKg/UXiE7KOFDqI/AAAAAAAAAcQ/ESRKpfZ4Gus/s1600/849-1234251683JKYT.jpg" width="400" /></a></div>
Experts estimate that more than 4 million people have the disease. <br />
<br />
This makes it the second most common rheumatic disease yet many people have never heard of it. <a href="http://sjogrenssyndrome.blogspot.com.au/2011/04/who-gets-sjogrens-syndrome.html" target="_blank">Read more...</a>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com4tag:blogger.com,1999:blog-480140972539070676.post-49708777937690686422013-04-20T14:32:00.004-07:002019-11-09T22:44:53.552-08:00What is Primary Sjogren's Syndrome<div class="separator" style="clear: both; text-align: center;">
</div>
<div class="separator" style="clear: both; text-align: center;">
<a href="https://1.bp.blogspot.com/-7dobhyhgDhQ/XcexcCkQjKI/AAAAAAAAAog/qsURR9FR5zka7_NSWQ0HCLrut9yOzzOBACLcBGAsYHQ/s1600/Sjogren%2527s%2BBlog%2B%25285%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Primary Sjogren's Syndrome" border="0" data-original-height="810" data-original-width="540" height="640" src="https://1.bp.blogspot.com/-7dobhyhgDhQ/XcexcCkQjKI/AAAAAAAAAog/qsURR9FR5zka7_NSWQ0HCLrut9yOzzOBACLcBGAsYHQ/s640/Sjogren%2527s%2BBlog%2B%25285%2529.jpg" title="What is Primary Sjogren's Syndrome" width="426" /></a></div>
<br />
<br />
<span style="font-family: inherit;">Primary <span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Sjögren’s Syndrome is a diagnosis given when the person has no other autoimmune disease. </span></span><br />
<span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"><span style="font-family: inherit;"><br /></span></span>
<span style="font-family: inherit;"><span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">This is not exactly true though as I was told I had Primary Sjogren's even though I had an autoimmune thyroid disease. </span> Apparently autoimmune thyroid diseases are so prevalent in people with SS that they have been taken out of the equation. </span><br />
<span style="font-family: inherit;"><br /></span>
<span style="font-family: inherit;"><span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">When Henrik Sjögren, the Swedish ophthalmologist, presented his thesis on</span> Sjögren's<span style="background-color: transparent; color: #222222; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> in 1933, there was no such thing as Primary and Secondary there was just the name <span style="background-color: transparent; color: black; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">Sjögren's syndrome. <span style="background-color: transparent; color: #111111; display: inline; float: none; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 18.1px; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;"> He wrote about 19 female patients with lacrimal dysfunction and dryness as keratoconjunctivitis sicca, meaning "inflammation of the cornea and conjunctiva" 13 of whom had arthritis. </span></span></span></span><br />
<b><span style="font-family: inherit;"><i><u><br /></u></i></span></b>
The symptoms of Sjögren’s Syndrome vary greatly between individuals and include a dryness <span class="highlightedSearchTerm">of</span> <span class="highlightedSearchTerm">the</span> mo<span class="highlightedSearchTerm">is</span>t areas <span class="highlightedSearchTerm">of</span> <span class="highlightedSearchTerm">the</span> body, like <span class="highlightedSearchTerm">the</span> mouth, eyes, ears, nose and vagina. Fatigue and depression, plus painful joints, are also associated with <span class="highlightedSearchTerm">the</span> d<span class="highlightedSearchTerm">is</span>ease.<br />
<br />
When organs other than the lacrimal and salivary glands are affected, this is known as “extraglandular involvement.” Usually, this occurs in patients with primary Sjögren’s syndrome (see “<a href="http://sjogrenssyndrome.blogspot.com.au/2013/03/do-i-have-primary-or-secondary-sjogrens.html" target="_blank">Primary Versus Secondary Sjögren’s Syndrome</a>”). <br />
<br />
Manifestations of Primary Sjögren’s Syndrome include :<br />
<ul>
<li>joint inflammation</li>
<li>particular forms of autoimmune thyroid, kidney, liver, lung, and skin disease</li>
<li>changes in nerve function of the upper or lower limbs </li>
<li><strong>small proportion</strong> of patients may progress to a form of lymphoma</li>
</ul>
Do you know if you have Primary or Secondary Sjögren’s Syndrome?<br />
Did your specialist define this for you?<br />
<span style="font-size: xx-small;"></span><br />
<span style="font-size: x-small;">RESOURCE: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)</span><br />
<ul>
</ul>
Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com13tag:blogger.com,1999:blog-480140972539070676.post-81803704822367857032013-04-14T20:33:00.003-07:002013-04-20T14:28:50.588-07:00Did you know April is Sjogren's Syndrome month?<div class="separator" style="clear: both; text-align: center;">
<a href="http://3.bp.blogspot.com/-08vQvJ0mAns/UWt0DDWCNZI/AAAAAAAAAbg/e4HIm-MbdJE/s1600/SSSS531584_341561062622395_1618406572_n.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-08vQvJ0mAns/UWt0DDWCNZI/AAAAAAAAAbg/e4HIm-MbdJE/s1600/SSSS531584_341561062622395_1618406572_n.jpg" height="308" width="400" /></a></div>
I am trying to post more often this month to help increase awareness of Sjogren's Syndrome. I figure it is the first, and basic step, in getting more research into this annoying condition.<br />
<span>Sjögren's </span>Syndrome Foundation is promoting <a href="http://info.sjogrens.org/bold-blue-day/" target="_blank"><strong>Bold Blue Day.</strong></a><br />
Do you know of anyone else doing something specially for Sjogren's awareness this month? Please let me know so I can post it here.<br />
Also if you would like to help spread the word please post this on your social networks using the handy little buttons below - Cheers.Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com1tag:blogger.com,1999:blog-480140972539070676.post-5457100593825266582013-04-09T01:44:00.004-07:002013-10-12T03:57:29.041-07:00Sjogren's fact of the week<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-QPq03WYwUYo/UWPUpD4kWqI/AAAAAAAAAbM/SZXctG003J4/s1600/Wheat,_rye,_triticale_montage.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" border="0" height="89" src="http://4.bp.blogspot.com/-QPq03WYwUYo/UWPUpD4kWqI/AAAAAAAAAbM/SZXctG003J4/s200/Wheat,_rye,_triticale_montage.jpg" title="Wheat, rye & triticale" width="200" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Gluten: Wheat, rye & triticale</td></tr>
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Biopsy of the small bowel revealed the occurrence of celiac<strong> like</strong> disease in 15% of Primary Sjogren's Syndrome patients.<br />
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<span style="font-family: Georgia;"><span style="font-family: inherit;">Want more information: Institute of Medical Technology, University of Tampere, Finland: </span></span><span style="font-family: Georgia;"><a href="http://www.edwardsdrugs.com/PDF/112100%20-%2015_0of%20all%20Sjogren%20pts%20with%20CD%20!.pdf" target="_blank"><span style="font-family: inherit;">Celiac disease and markers of celiac disease latency in patients with</span></a><br />
<a href="http://www.edwardsdrugs.com/PDF/112100%20-%2015_0of%20all%20Sjogren%20pts%20with%20CD%20!.pdf" target="_blank"><span style="font-family: inherit;">primary Sjögren's syndrome.</span></a><br />
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Read more about gluten (wheat, rye and triticale) and Sjogren's Syndrome and my personal story <a href="http://sjogrenssyndrome.blogspot.com.au/2012/08/gluten-and-sjogrens.html"><strong>here.</strong></a></span><br />
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<span style="font-family: Georgia;">Do you have a problem with gluten?</span></div>
<br />Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-43397041432076652792013-04-07T15:50:00.001-07:002013-04-07T15:50:26.536-07:00What affects your dryness in Sjogren's?<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://2.bp.blogspot.com/-PDfTNGqBqI0/UWH34cBsM0I/AAAAAAAAAa8/BFloS3pZ9n0/s1600/sugar%2520on%2520spoon%2520doctored-md.png" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img alt="sugar and health concerns" border="0" src="http://2.bp.blogspot.com/-PDfTNGqBqI0/UWH34cBsM0I/AAAAAAAAAa8/BFloS3pZ9n0/s1600/sugar%2520on%2520spoon%2520doctored-md.png" title="sugar is causing mouth dryness" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Have you noticed a problem with sugar and your health?</td></tr>
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I have found a few things that <strong>increase my</strong> Sjogren's dryness in my mouth. Obviously salt and soy sauce and take away foods that are full of salt but also tea. Yes plain ordinary tea. I drink it with skim milk and almost 1 sugar. Whenever I have a cup of tea my tongue gets sore afterwards, almost as if the tea has burnt it but I am not drinking it very hot.<br />
Now I have found something that actually decreases my mouth dryness! SUGAR. I don't mean eating sugar, I mean removing sugar from my diet. The added bonus is when I don't use sugar I don't enjoy tea so it kills two birds with one stone. The dehydrating effect of tea is gone and the sugar is gone too.<br />
If you are interested in quitting sugar I have found a great book called The 21 Day Sugar Detox which gives a step-by-step program, recipes, guidance including daily emails and an online community. <a href="http://6dbd3auahgjbax22i6mfu3wybr.hop.clickbank.net/" target="_top">Click Here!</a>
if you want to find out more.Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com0tag:blogger.com,1999:blog-480140972539070676.post-80685718133779039202013-03-26T15:12:00.002-07:002015-04-12T23:38:16.811-07:00Do I have Primary or Secondary Sjogren's Syndrome?<h3>
Primary Versus Secondary Sjögren’s Syndrome</h3>
Sjögren’s syndrome is classified as either primary or secondary. <br />
Both are systemic diseases, meaning they can affect many systems in the body, and they occur with about equal frequency. <br />
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The primary form causes early and gradually progressive decreased function in the lacrimal and salivary glands, and can include a variety of extraglandular conditions. <br />
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The secondary form occurs in people who already have another autoimmune connective tissue disease, most commonly rheumatoid arthritis or systemic lupus erythematosus. These people then develop dry eyes or dry mouth.<br />
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Some people with Sjögren’s syndrome have certain autoantibodies circulating in their blood called “anti-SS-A” and “anti-SS-B.” They are strongly but not exclusively associated with Sjögren’s syndrome. Other people with clear evidence of primary Sjögren’s syndrome do not have those antibodies.<br />
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Although people with secondary Sjögren’s syndrome generally have less severe ocular and oral problems than those with the primary form, they also have to contend with the effects of their primary disease (i.e., <a href="http://rheumatoidarthritisstories.blogspot.com.au/" target="_blank"><strong>rheumatoid arthritis</strong></a>, systemic lupus erythematosus, etc.).<br />
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FROM: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) <br />
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Do you know if you have Primary or Secondary Sjogren's Syndrome?Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com2tag:blogger.com,1999:blog-480140972539070676.post-63080685738062598202013-03-24T15:41:00.001-07:002013-10-12T04:16:27.576-07:00Why You Should Be Drinking Green Tea with Sjogren's Syndrome<div class="separator" style="clear: both; text-align: center;">
<a href="http://3.bp.blogspot.com/-D3Ko0y0v34k/UU-ApjC0raI/AAAAAAAAAac/qGY8mwlaxGs/s1600/teaimagesCAIX2E9T.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-D3Ko0y0v34k/UU-ApjC0raI/AAAAAAAAAac/qGY8mwlaxGs/s1600/teaimagesCAIX2E9T.jpg" /></a></div>
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GREEN TEA may prevent or slow down autoimmune diseases. It is a natural treatment being studied by Dr. Stephen Hsu, a researcher in the Medical College of Georgia, USA. A component of green tea called EGCG helps suppress inflammation, according to Dr. Hsu and hi colleagues. <br />
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Dr. Hsu's study, at the Medical College of Georgia, USA, found much less damage in the salivary glands in the group treated with green tea extract. About 30% of elderly Americans suffer from degrees of dry mouth, while only 5% of the elderly in China, where green tea is widely consumed, suffer from the problem.</div>
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Dr. Hsu says “EGCG...significantly lowered the serum autoantibodies, reducing the severity of Sjögren’s Syndrome-like symptoms.”</div>
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EGCG is Green Tea catechin.<br />
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"The benefit of using green tea in preventing or slowing these autoimmune diseases is that it's natural and not known to harm the body," says Dr. Kevin Gillespie, first author of the study. <br />
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<a href="http://www.sciencedaily.com/releases/2008/10/081023144119.htm" target="_blank">More Reasons Why You Should Be Drinking Green Tea</a> – for Type 1 Diabetes & Sjogren’s Syndrome. </div>
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I am trying to quit ordinary tea (AGAIN) and drink green tea. I am hoping it reduces the common symptom known as dry mouth.<br />
How about you? What do you drink? Black, green, both or none?Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com9tag:blogger.com,1999:blog-480140972539070676.post-6255027574379381742013-03-19T18:12:00.001-07:002015-04-13T01:54:04.826-07:00New gum for dry mouth in Sjogren's Syndrome<div style="-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; color: #3f3f3f; font-size-adjust: none; font-stretch: normal; font: small/normal verdana; letter-spacing: normal; margin-top: 10px; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px;">
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<span style="font-family: inherit;">A worrying symptom of Sjogren's Syndrome is dryness of the mouth, which can lead to dental problems and a cough. A chewing gum called MighTeaFlow is now available for dry mouth.</span></div>
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<span style="font-family: inherit;">Helps reduce bacteria that flourish in a dry mouth, causing plaque and
tooth decay
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<li><span style="font-family: inherit;">Helps relieve mouth dryness without side effects with all the benefits
of green tea and Xylitol
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<li><span style="font-family: inherit;">Naturally stimulates salivary flow. </span></li>
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<span style="font-family: inherit;">Xylitol helps prevent dental decay and stimulates saliva. </span><br />
<span style="font-family: inherit;">Jaborandi leaf extract is a herb that has been used in South American countries for centuries to increase secretion.<strong><span class="Apple-converted-space"> </span></strong></span><br />
<span style="font-family: inherit;">Developed by Dr. Stephen Hsu, a professor at Georgia Health Sciences University, College of Dental Medicine.</span></div>
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<span style="font-family: inherit;">It is made in the USA at FDA-Approved Manufacturing Facilities – U.S. Patent Technology. I have not seen this product in Australia yet. Is anyone using this gum and what do you think of it?</span><br />
<span style="font-family: inherit;">The only place I can find to purchase it is </span><a href="https://www.camellix.com/products/mighteaflow%C2%AE-dry-mouth-chewing-gum" target="_blank"><span style="font-family: inherit;">here.</span></a><br />
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<img alt="gum for dry mouth " border="0" src="http://3.bp.blogspot.com/-9gr1ffxk1x4/UUkMxIKxR7I/AAAAAAAAAYc/MSAZdGjaVwY/s1600/gum.jpg" title="symptom of Sjogren's Syndrome is dryness of the mouth" /></div>
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<span style="font-family: inherit;">DISCLAIMER: I am not affiliated with this product in any way and do not get paid when you purchase their product.</span><br />
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Do you have a favourite gum or dental product that you use for your Sjogren's?<br />
<span style="font-size: x-small;"></span>Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com4tag:blogger.com,1999:blog-480140972539070676.post-87477003838029879302013-03-16T05:59:00.001-07:002015-04-13T02:30:35.392-07:00Protecting your eyes with Sjogren's syndrome or Sunglasses Dilemma<br />
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<a href="http://1.bp.blogspot.com/-ftnSdt1YIO8/VSuMOezQJLI/AAAAAAAAAg0/2byLUQOuO2Q/s1600/ss%2Bimages4FR6MIBD.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Sunglasses and Sjogren's" border="0" src="http://1.bp.blogspot.com/-ftnSdt1YIO8/VSuMOezQJLI/AAAAAAAAAg0/2byLUQOuO2Q/s1600/ss%2Bimages4FR6MIBD.jpg" height="206" title="Protecting your eyes with Sjogren's syndrome" width="320" /></a></div>
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I can't go out of the house anymore without my eyes being so aggrevated the rims turn red and I look like I've been crying. I wear multifocals normally and here begins the dilemma. What to wear to protect my eyes from glare? Only another person who wears multifocals will understand.<br />
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If I use normal sunglasses I am as blind as a bat.<br />
I bought some clip ons and lost them and they may also scratch the lens of the multifocals. (Also my daughter tells me they are not cool!)<br />
Apparently you can get wrap arounds that fit around the top of other glasses but they are expensive and block your vision. So the dilemma continues!Lee @ sjogrens blog http://www.blogger.com/profile/15728445089750426476noreply@blogger.com6